Drug interactions
Finerenone + Isoniazid
Severity: Moderate
Finerenone and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is cleared mainly by CYP3A4, so inhibition of this enzyme can increase its exposure and the risk of hyperkalemia and renal function decline. Isoniazid is a relatively weak CYP3A4 inhibitor, so the effect is probably limited but not well characterized.
What this interaction means in plain words
Finerenone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, decreasing the clearance of finerenone.
What to do
Check serum potassium and renal function when starting or stopping isoniazid and adjust the finerenone dose according to potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Isoniazid?
MediHelp rates the interaction as moderate. Finerenone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Finerenone is cleared mainly by CYP3A4, so inhibition of this enzyme can increase its exposure and the risk of hyperkalemia and renal function decline. Isoniazid is a relatively weak CYP3A4 inhibitor, so the effect is probably limited but not well characterized.
How serious is the interaction between Finerenone and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting or stopping isoniazid and adjust the finerenone dose according to potassium results.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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