Drug interactions
Finerenone + Perindopril
Severity: Major
Finerenone and Perindopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a mineralocorticoid receptor antagonist and ACE inhibitors reduce aldosterone, and both raise serum potassium. Together they increase the risk of clinically significant hyperkalemia, particularly in patients with renal impairment.
What this interaction means in plain words
Finerenone and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Finerenone belongs to Cardiovascular; Perindopril belongs to Cardiovascular.
Why it happens
Additive potassium retention through mineralocorticoid receptor blockade and reduced aldosterone production.
What to do
Measure serum potassium and renal function before starting and during the first weeks, then periodically, and adjust or interrupt finerenone per labeling according to potassium level. Avoid additional potassium supplements or potassium-sparing agents.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Perindopril?
MediHelp rates the interaction as major. Finerenone and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Finerenone is a mineralocorticoid receptor antagonist and ACE inhibitors reduce aldosterone, and both raise serum potassium. Together they increase the risk of clinically significant hyperkalemia, particularly in patients with renal impairment.
How serious is the interaction between Finerenone and Perindopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium and renal function before starting and during the first weeks, then periodically, and adjust or interrupt finerenone per labeling according to potassium level. Avoid additional potassium supplements or potassium-sparing agents.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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