Drug interactions
Fingolimod + Fluphenazine
Severity: Major
Fingolimod and Fluphenazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can cause bradycardia and conduction delay after the first dose and has been associated with QT prolongation. Fluphenazine also prolongs the QT interval, so the risk of serious arrhythmia including torsades de pointes is increased.
What this interaction means in plain words
Fingolimod and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with fingolimod-induced bradycardia increasing susceptibility.
What to do
Obtain a baseline ECG and observe the patient after the first fingolimod dose, with extended monitoring in those on QT-prolonging drugs. Consider switching one agent if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Fluphenazine?
MediHelp rates the interaction as major. Fingolimod and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod can cause bradycardia and conduction delay after the first dose and has been associated with QT prolongation. Fluphenazine also prolongs the QT interval, so the risk of serious arrhythmia including torsades de pointes is increased.
How serious is the interaction between Fingolimod and Fluphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and observe the patient after the first fingolimod dose, with extended monitoring in those on QT-prolonging drugs. Consider switching one agent if QTc is prolonged.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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