Drug interactions
Fingolimod + Fluvoxamine
Severity: Moderate
Fingolimod and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia on initiation and has been associated with QT prolongation, and fluvoxamine adds a small QT effect. Bradycardia and QT prolongation together increase the risk of arrhythmia.
What this interaction means in plain words
Fingolimod and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and bradycardia-related arrhythmia risk.
What to do
Perform first-dose cardiac monitoring per fingolimod labeling and obtain an ECG beforehand, and seek cardiology advice if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Fluvoxamine?
MediHelp rates the interaction as moderate. Fingolimod and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia on initiation and has been associated with QT prolongation, and fluvoxamine adds a small QT effect. Bradycardia and QT prolongation together increase the risk of arrhythmia.
How serious is the interaction between Fingolimod and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform first-dose cardiac monitoring per fingolimod labeling and obtain an ECG beforehand, and seek cardiology advice if QT risk factors are present.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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