Drug interactions
Fingolimod + Gemcitabine
Severity: Major
Fingolimod and Gemcitabine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine causes myelosuppression, including neutropenia and thrombocytopenia. Combined with fingolimod, infection risk may be increased.
What this interaction means in plain words
Fingolimod and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Gemcitabine belongs to Oncology.
Why it happens
Additive immunosuppression from lymphocyte sequestration and cytotoxic marrow suppression.
What to do
Monitor blood counts and infection signs closely. Consider interrupting fingolimod during chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Gemcitabine
Frequently asked questions
Can I take Fingolimod with Gemcitabine?
MediHelp rates the interaction as major. Fingolimod and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemcitabine causes myelosuppression, including neutropenia and thrombocytopenia. Combined with fingolimod, infection risk may be increased.
How serious is the interaction between Fingolimod and Gemcitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs closely. Consider interrupting fingolimod during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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