Drug interactions
Fingolimod + Gilteritinib
Severity: Moderate
Fingolimod and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and fingolimod slows heart rate, which increases the risk of torsades de pointes. The combination may be hazardous in patients with other risk factors.
What this interaction means in plain words
Fingolimod and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation with fingolimod-induced bradycardia.
What to do
Obtain a baseline ECG and monitor ECG periodically, correcting potassium and magnesium. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Fingolimod with Gilteritinib?
MediHelp rates the interaction as moderate. Fingolimod and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and fingolimod slows heart rate, which increases the risk of torsades de pointes. The combination may be hazardous in patients with other risk factors.
How serious is the interaction between Fingolimod and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG periodically, correcting potassium and magnesium. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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