Drug interactions
Fingolimod + Indacaterol-glycopyrronium
Severity: Moderate
Fingolimod and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can prolong the QT interval, especially after the first dose. Indacaterol may add modest repolarization effects and hypokalemia, increasing arrhythmia risk in susceptible patients.
What this interaction means in plain words
Fingolimod and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Perform first-dose cardiac monitoring as per fingolimod labeling and review ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Fingolimod and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and can prolong the QT interval, especially after the first dose. Indacaterol may add modest repolarization effects and hypokalemia, increasing arrhythmia risk in susceptible patients.
How serious is the interaction between Fingolimod and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform first-dose cardiac monitoring as per fingolimod labeling and review ECG and electrolytes in patients with cardiac risk factors. Correct hypokalemia.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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