Drug interactions
Fingolimod + Labetalol
Severity: Major
Fingolimod and Labetalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod slows heart rate when started, and beta-blockers add to this effect, increasing the risk of significant bradycardia and AV block. The risk is greatest in the hours after the first dose or after a treatment interruption.
What this interaction means in plain words
Fingolimod and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Labetalol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic effects: fingolimod activates cardiac sphingosine-1-phosphate receptors while labetalol blocks beta receptors.
What to do
Obtain an ECG before starting fingolimod and monitor heart rate and blood pressure for at least 6 hours after the first dose. Consider an alternative to the beta-blocker if feasible, or extend monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Labetalol?
MediHelp rates the interaction as major. Fingolimod and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod slows heart rate when started, and beta-blockers add to this effect, increasing the risk of significant bradycardia and AV block. The risk is greatest in the hours after the first dose or after a treatment interruption.
How serious is the interaction between Fingolimod and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting fingolimod and monitor heart rate and blood pressure for at least 6 hours after the first dose. Consider an alternative to the beta-blocker if feasible, or extend monitoring.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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