Drug interactions
Fingolimod + Macimorelin
Severity: Moderate
Fingolimod and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin has a QT-prolonging effect and fingolimod can cause bradycardia and QT effects. Together they may increase the risk of ventricular arrhythmia during the diagnostic test.
What this interaction means in plain words
Fingolimod and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QTc prolongation, with fingolimod bradycardia as a contributing factor.
What to do
Consider alternative diagnostic testing for growth hormone deficiency in patients on fingolimod. If macimorelin is used, check a baseline ECG and electrolytes and monitor for arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Fingolimod with Macimorelin?
MediHelp rates the interaction as moderate. Fingolimod and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin has a QT-prolonging effect and fingolimod can cause bradycardia and QT effects. Together they may increase the risk of ventricular arrhythmia during the diagnostic test.
How serious is the interaction between Fingolimod and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative diagnostic testing for growth hormone deficiency in patients on fingolimod. If macimorelin is used, check a baseline ECG and electrolytes and monitor for arrhythmia.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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