Drug interactions
Fingolimod + Mefloquine
Severity: Major
Fingolimod and Mefloquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia after the first dose and has been associated with QT prolongation, and mefloquine also affects cardiac conduction. Using them together may raise the risk of bradyarrhythmia and torsades de pointes.
What this interaction means in plain words
Fingolimod and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive bradycardia and QT prolongation.
What to do
Avoid starting fingolimod in patients on mefloquine where possible. If unavoidable, use extended ECG monitoring at first dose and seek cardiology input.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Mefloquine?
MediHelp rates the interaction as major. Fingolimod and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes bradycardia after the first dose and has been associated with QT prolongation, and mefloquine also affects cardiac conduction. Using them together may raise the risk of bradyarrhythmia and torsades de pointes.
How serious is the interaction between Fingolimod and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting fingolimod in patients on mefloquine where possible. If unavoidable, use extended ECG monitoring at first dose and seek cardiology input.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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