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Drug interactions

Fingolimod + Mycophenolate mofetil

Severity: Major

Fingolimod and Mycophenolate mofetil: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Both drugs suppress immune function, so combined use may increase the risk of serious infections. Fingolimod lowers circulating lymphocytes, which adds to the effect of mycophenolate on lymphocyte proliferation.

What this interaction means in plain words

Fingolimod and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fingolimod belongs to Central Nervous System; Mycophenolate mofetil belongs to Miscellaneous.

Evidence level: Moderate

Why it happens

Additive immunosuppression through lymphocyte sequestration (fingolimod) and inhibition of lymphocyte proliferation (mycophenolate).

What to do

Avoid combining unless clearly needed; if used, monitor lymphocyte counts and watch closely for infection. Allow for the persistent effects of prior immunosuppressants when switching therapy.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Fingolimod with Mycophenolate mofetil?

MediHelp rates the interaction as major. Fingolimod and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so combined use may increase the risk of serious infections. Fingolimod lowers circulating lymphocytes, which adds to the effect of mycophenolate on lymphocyte proliferation.

How serious is the interaction between Fingolimod and Mycophenolate mofetil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed; if used, monitor lymphocyte counts and watch closely for infection. Allow for the persistent effects of prior immunosuppressants when switching therapy.

What other medicines interact with Mycophenolate mofetil?

MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.

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