Drug interactions
Fingolimod + Rilonacept
Severity: Moderate
Fingolimod and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 signalling and can increase susceptibility to infection. Together with fingolimod's lymphocyte-lowering effect, the risk of infection may be greater.
What this interaction means in plain words
Fingolimod and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-1 blockade and lymphocyte sequestration.
What to do
Monitor for signs of infection and check lymphocyte counts. Interrupt either drug if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Fingolimod with Rilonacept?
MediHelp rates the interaction as moderate. Fingolimod and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 signalling and can increase susceptibility to infection. Together with fingolimod's lymphocyte-lowering effect, the risk of infection may be greater.
How serious is the interaction between Fingolimod and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check lymphocyte counts. Interrupt either drug if a serious infection develops.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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