Drug interactions
Fingolimod + Solifenacin
Severity: Moderate
Fingolimod and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can prolong the QT interval after the first dose. Combined with solifenacin, which may have QT effects, the risk of arrhythmia may be higher in susceptible patients.
What this interaction means in plain words
Fingolimod and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with bradycardia from fingolimod increasing proarrhythmic susceptibility.
What to do
Perform ECG monitoring during fingolimod initiation and in patients with cardiac risk factors. Correct electrolytes and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Solifenacin?
MediHelp rates the interaction as moderate. Fingolimod and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and can prolong the QT interval after the first dose. Combined with solifenacin, which may have QT effects, the risk of arrhythmia may be higher in susceptible patients.
How serious is the interaction between Fingolimod and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring during fingolimod initiation and in patients with cardiac risk factors. Correct electrolytes and review other QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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