Drug interactions
Fingolimod + Trastuzumab deruxtecan
Severity: Moderate
Fingolimod and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan can cause neutropenia and interstitial lung disease, and fingolimod lowers lymphocyte counts. The combination may raise infection risk, including pulmonary infection that complicates assessment of lung toxicity.
What this interaction means in plain words
Fingolimod and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive pharmacodynamic immunosuppression; no pharmacokinetic effect on fingolimod levels is established.
What to do
Monitor blood counts and infection signs, and evaluate new respiratory symptoms promptly. Consider holding fingolimod during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Fingolimod with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Fingolimod and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan can cause neutropenia and interstitial lung disease, and fingolimod lowers lymphocyte counts. The combination may raise infection risk, including pulmonary infection that complicates assessment of lung toxicity.
How serious is the interaction between Fingolimod and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs, and evaluate new respiratory symptoms promptly. Consider holding fingolimod during treatment.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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