Drug interactions
Flavoxate + Levodopa
Severity: Minor
Flavoxate and Levodopa: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flavoxate has antimuscarinic activity that may add to the effect of levodopa on tremor but may worsen dyskinesia. Slowed gastric motility may also reduce levodopa absorption.
What this interaction means in plain words
Flavoxate and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flavoxate belongs to Genitourinary; Levodopa belongs to Central Nervous System.
Why it happens
Anticholinergic pharmacodynamic effects and delayed gastric emptying that may reduce levodopa absorption.
What to do
Monitor motor symptoms and dyskinesia, and adjust the levodopa dose if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Flavoxate with Levodopa?
MediHelp rates the interaction as minor. Flavoxate and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flavoxate has antimuscarinic activity that may add to the effect of levodopa on tremor but may worsen dyskinesia. Slowed gastric motility may also reduce levodopa absorption.
How serious is the interaction between Flavoxate and Levodopa?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and dyskinesia, and adjust the levodopa dose if the response changes.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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