Drug interactions
Flecainide + Fluticasone-vilanterol
Severity: Major
Flecainide and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide slows cardiac conduction and is proarrhythmic, while vilanterol can cause tachycardia and hypokalemia. Together they may increase risk of ventricular arrhythmias, especially in structural heart disease.
What this interaction means in plain words
Flecainide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects, with beta-agonist-induced hypokalemia and increased heart rate.
What to do
Monitor ECG (QRS and QTc), heart rate and potassium when combined. Choose an alternative bronchodilator if arrhythmias or symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Flecainide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flecainide slows cardiac conduction and is proarrhythmic, while vilanterol can cause tachycardia and hypokalemia. Together they may increase risk of ventricular arrhythmias, especially in structural heart disease.
How serious is the interaction between Flecainide and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QRS and QTc), heart rate and potassium when combined. Choose an alternative bronchodilator if arrhythmias or symptoms occur.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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