Drug interactions
Flecainide + Histrelin
Severity: Moderate
Flecainide and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with histrelin can prolong the QT interval, which may add to flecainide's proarrhythmic effects. The risk is greater with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Flecainide and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Histrelin belongs to Musculoskeletal.
Why it happens
Androgen deprivation therapy prolongs QT, additive with flecainide.
What to do
Monitor ECG periodically and correct electrolytes. Consider whether flecainide is appropriate in patients with structural heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Flecainide with Histrelin?
MediHelp rates the interaction as moderate. Flecainide and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with histrelin can prolong the QT interval, which may add to flecainide's proarrhythmic effects. The risk is greater with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Flecainide and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG periodically and correct electrolytes. Consider whether flecainide is appropriate in patients with structural heart disease.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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