Drug interactions
Flecainide + Mifepristone
Severity: Major
Flecainide and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone prolongs the QT interval, and with flecainide this may increase the risk of torsades de pointes and proarrhythmia. Mifepristone also inhibits CYP3A4 and may inhibit CYP2D6, which could affect flecainide exposure.
What this interaction means in plain words
Flecainide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation with possible CYP inhibition by mifepristone.
What to do
Use an alternative if available; if not, obtain an ECG, correct electrolytes and monitor for arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Flecainide with Mifepristone?
MediHelp rates the interaction as major. Flecainide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone prolongs the QT interval, and with flecainide this may increase the risk of torsades de pointes and proarrhythmia. Mifepristone also inhibits CYP3A4 and may inhibit CYP2D6, which could affect flecainide exposure.
How serious is the interaction between Flecainide and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative if available; if not, obtain an ECG, correct electrolytes and monitor for arrhythmia.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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