Drug interactions
Flecainide + Quizartinib
Severity: Major
Flecainide and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-related QT prolongation and has a boxed warning for torsades de pointes. Adding flecainide increases the risk of life-threatening arrhythmia.
What this interaction means in plain words
Flecainide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation and cardiac ion channel effects.
What to do
Avoid if possible. If unavoidable, monitor ECG frequently, correct electrolytes, and reduce the quizartinib dose where labeling advises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flecainide and Quizartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Flecainide with Quizartinib?
MediHelp rates the interaction as major. Flecainide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-related QT prolongation and has a boxed warning for torsades de pointes. Adding flecainide increases the risk of life-threatening arrhythmia.
How serious is the interaction between Flecainide and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor ECG frequently, correct electrolytes, and reduce the quizartinib dose where labeling advises.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
