Drug interactions
Flecainide + Umeclidinium-vilanterol
Severity: Major
Flecainide and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flecainide slows cardiac conduction and can be proarrhythmic, and vilanterol may cause tachycardia and hypokalemia that can heighten that risk. Combined use may increase the likelihood of ventricular arrhythmia, especially in structural heart disease.
What this interaction means in plain words
Flecainide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flecainide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects through conduction slowing and beta-adrenergic stimulation with possible hypokalemia.
What to do
Monitor ECG, heart rate and serum potassium, and correct deficits. Consider an alternative bronchodilator in patients with significant heart disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Flecainide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flecainide slows cardiac conduction and can be proarrhythmic, and vilanterol may cause tachycardia and hypokalemia that can heighten that risk. Combined use may increase the likelihood of ventricular arrhythmia, especially in structural heart disease.
How serious is the interaction between Flecainide and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and serum potassium, and correct deficits. Consider an alternative bronchodilator in patients with significant heart disease.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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