Drug interactions
Fleroxacin + Glipizide
Severity: Moderate
Fleroxacin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients on sulfonylureas, with severe hypoglycemia reported especially in older adults and those with renal impairment.
What this interaction means in plain words
Fleroxacin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones block pancreatic beta-cell potassium channels and stimulate insulin release, adding to sulfonylurea effects.
What to do
Monitor blood glucose closely during fluoroquinolone therapy and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if marked dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fleroxacin and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide
Frequently asked questions
Can I take Fleroxacin with Glipizide?
MediHelp rates the interaction as moderate. Fleroxacin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients on sulfonylureas, with severe hypoglycemia reported especially in older adults and those with renal impairment.
How serious is the interaction between Fleroxacin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during fluoroquinolone therapy and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if marked dysglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
