Drug interactions
Flibanserin + Glyburide-metformin
Severity: Moderate
Flibanserin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide is a weak CYP3A4 inhibitor and may modestly raise flibanserin concentrations. Higher flibanserin exposure increases the risk of hypotension, syncope and CNS depression, particularly if other CYP3A4 inhibitors are also taken or alcohol is consumed.
What this interaction means in plain words
Flibanserin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Glyburide-metformin belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated flibanserin metabolism.
What to do
Counsel the patient about dizziness, sedation and fainting, and avoid adding further CYP3A4 inhibitors or alcohol. Reassess flibanserin tolerability if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Flibanserin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide is a weak CYP3A4 inhibitor and may modestly raise flibanserin concentrations. Higher flibanserin exposure increases the risk of hypotension, syncope and CNS depression, particularly if other CYP3A4 inhibitors are also taken or alcohol is consumed.
How serious is the interaction between Flibanserin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness, sedation and fainting, and avoid adding further CYP3A4 inhibitors or alcohol. Reassess flibanserin tolerability if symptoms appear.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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