Drug interactions
Flibanserin + Istradefylline
Severity: Moderate
Flibanserin and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline raises exposure to CYP3A4 substrates. Increased flibanserin exposure may lead to more hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at 40 mg/day inhibits CYP3A4, reducing flibanserin clearance.
What to do
Monitor for dizziness, hypotension and sedation, particularly with the higher istradefylline dose. Counsel the patient about bedtime dosing of flibanserin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Flibanserin with Istradefylline?
MediHelp rates the interaction as moderate. Flibanserin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses istradefylline raises exposure to CYP3A4 substrates. Increased flibanserin exposure may lead to more hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation, particularly with the higher istradefylline dose. Counsel the patient about bedtime dosing of flibanserin.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
