Drug interactions
Flibanserin + Lidocaine
Severity: Minor
Flibanserin and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 inhibitor in systemic use, and flibanserin exposure may rise modestly, increasing the risk of hypotension, syncope and sedation. The legacy contraindication applies to moderate or strong inhibitors, which lidocaine is not.
What this interaction means in plain words
Flibanserin and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Lidocaine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by lidocaine may slightly increase flibanserin levels.
What to do
No routine change is needed. Counsel the patient about dizziness and avoid alcohol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Flibanserin with Lidocaine?
MediHelp rates the interaction as minor. Flibanserin and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 inhibitor in systemic use, and flibanserin exposure may rise modestly, increasing the risk of hypotension, syncope and sedation. The legacy contraindication applies to moderate or strong inhibitors, which lidocaine is not.
How serious is the interaction between Flibanserin and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Counsel the patient about dizziness and avoid alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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