Drug interactions
Flibanserin + Lorazepam
Severity: Moderate
Flibanserin and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together increases drowsiness, sedation and impaired alertness. Flibanserin labeling warns of additive CNS depression with other CNS depressants, which may affect driving and daily activities.
What this interaction means in plain words
Flibanserin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Lorazepam belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from flibanserin and the benzodiazepine.
What to do
Counsel the patient about sedation and avoid driving until the combined effect is known. Consider dose reduction or an alternative if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Lorazepam
Frequently asked questions
Can I take Flibanserin with Lorazepam?
MediHelp rates the interaction as moderate. Flibanserin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together increases drowsiness, sedation and impaired alertness. Flibanserin labeling warns of additive CNS depression with other CNS depressants, which may affect driving and daily activities.
How serious is the interaction between Flibanserin and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about sedation and avoid driving until the combined effect is known. Consider dose reduction or an alternative if excessive sedation develops.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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