Drug interactions
Flibanserin + Methadone
Severity: Moderate
Flibanserin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can deepen sedation, dizziness and the risk of syncope. Methadone is a minor CYP3A4 substrate with no clear inhibitory effect, so a pharmacokinetic rise in flibanserin is unlikely to matter.
What this interaction means in plain words
Flibanserin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from both drugs.
What to do
Monitor for excessive sedation, hypotension and syncope, especially when starting or increasing either drug. Advise the patient to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Flibanserin with Methadone?
MediHelp rates the interaction as moderate. Flibanserin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can deepen sedation, dizziness and the risk of syncope. Methadone is a minor CYP3A4 substrate with no clear inhibitory effect, so a pharmacokinetic rise in flibanserin is unlikely to matter.
How serious is the interaction between Flibanserin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, hypotension and syncope, especially when starting or increasing either drug. Advise the patient to avoid driving until the response is known.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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