Drug interactions
Flibanserin + Morphine
Severity: Moderate
Flibanserin and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine and flibanserin both cause sedation and can lower alertness. Combined use may increase drowsiness, dizziness and impaired performance, and may add to hypotension.
What this interaction means in plain words
Flibanserin and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Morphine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression from flibanserin and the opioid.
What to do
Advise the patient to avoid driving until the response is known. Use the lowest effective morphine dose and monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Flibanserin with Morphine?
MediHelp rates the interaction as moderate. Flibanserin and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Morphine and flibanserin both cause sedation and can lower alertness. Combined use may increase drowsiness, dizziness and impaired performance, and may add to hypotension.
How serious is the interaction between Flibanserin and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid driving until the response is known. Use the lowest effective morphine dose and monitor for excess sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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