Drug interactions
Flibanserin + Paroxetine
Severity: Moderate
Flibanserin and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor, and flibanserin is partly metabolized by CYP2C19 and CYP3A4. Exposure can rise and bring more hypotension, syncope and sedation, and both drugs act on serotonergic pathways.
What this interaction means in plain words
Flibanserin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Paroxetine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition and additive serotonergic and CNS effects.
What to do
Monitor for dizziness, syncope and sedation. Counsel the patient about alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Paroxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Flibanserin with Paroxetine?
MediHelp rates the interaction as moderate. Flibanserin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor, and flibanserin is partly metabolized by CYP2C19 and CYP3A4. Exposure can rise and bring more hypotension, syncope and sedation, and both drugs act on serotonergic pathways.
How serious is the interaction between Flibanserin and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, syncope and sedation. Counsel the patient about alcohol avoidance.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
