Drug interactions
Flibanserin + Quinine
Severity: Moderate
Flibanserin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits intestinal P-glycoprotein and may raise quinine exposure, and quinine is a narrow-therapeutic-index drug with dose-related toxicity such as cinchonism and QT prolongation. Quinine is also a weak CYP3A4 inhibitor, which could modestly raise flibanserin levels and its sedative and hypotensive effects.
What this interaction means in plain words
Flibanserin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Quinine belongs to Anti Parasitic.
Why it happens
Flibanserin inhibits P-glycoprotein, and quinine weakly inhibits CYP3A4, so each may raise the other's exposure.
What to do
Monitor for quinine toxicity (tinnitus, QT prolongation, arrhythmia) and for flibanserin-related dizziness, sedation and hypotension. Consider ECG monitoring if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Flibanserin with Quinine?
MediHelp rates the interaction as moderate. Flibanserin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits intestinal P-glycoprotein and may raise quinine exposure, and quinine is a narrow-therapeutic-index drug with dose-related toxicity such as cinchonism and QT prolongation. Quinine is also a weak CYP3A4 inhibitor, which could modestly raise flibanserin levels and its sedative and hypotensive effects.
How serious is the interaction between Flibanserin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity (tinnitus, QT prolongation, arrhythmia) and for flibanserin-related dizziness, sedation and hypotension. Consider ECG monitoring if other QT-prolonging drugs are present.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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