Drug interactions
Flibanserin + Suvorexant
Severity: Moderate
Flibanserin and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence. Combined use may increase next-day drowsiness and impair alertness and coordination.
What this interaction means in plain words
Flibanserin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Suvorexant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression (orexin antagonism plus sedating effects of flibanserin).
What to do
Warn patients about additive sedation and avoid driving or hazardous activities until effects are known. Use the lowest effective suvorexant dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Flibanserin with Suvorexant?
MediHelp rates the interaction as moderate. Flibanserin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence. Combined use may increase next-day drowsiness and impair alertness and coordination.
How serious is the interaction between Flibanserin and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive sedation and avoid driving or hazardous activities until effects are known. Use the lowest effective suvorexant dose.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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