Drug interactions
Fluconazole + Fosamprenavir
Severity: Moderate
Fluconazole and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase amprenavir exposure by inhibiting CYP3A4. Studies suggest the effect is modest and usually of limited clinical consequence.
What this interaction means in plain words
Fluconazole and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of amprenavir, the active form of fosamprenavir, by fluconazole.
What to do
No routine dose adjustment is required. Monitor for protease inhibitor adverse effects such as rash and gastrointestinal upset.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Fosamprenavir?
MediHelp rates the interaction as moderate. Fluconazole and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase amprenavir exposure by inhibiting CYP3A4. Studies suggest the effect is modest and usually of limited clinical consequence.
How serious is the interaction between Fluconazole and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required. Monitor for protease inhibitor adverse effects such as rash and gastrointestinal upset.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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