Drug interactions
Fluconazole + Gemtuzumab
Severity: Moderate
Fluconazole and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a labeled warning regarding QT prolongation and fluconazole can also prolong the QT interval. Together they may increase the risk of ventricular arrhythmias including torsades de pointes, especially with electrolyte disturbances, which are common in patients with leukemia.
What this interaction means in plain words
Fluconazole and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QTc interval).
What to do
Check an ECG and electrolytes (potassium, magnesium, calcium) before treatment and monitor periodically, correcting abnormalities. Consider an alternative antifungal with less QT effect if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Gemtuzumab?
MediHelp rates the interaction as moderate. Fluconazole and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a labeled warning regarding QT prolongation and fluconazole can also prolong the QT interval. Together they may increase the risk of ventricular arrhythmias including torsades de pointes, especially with electrolyte disturbances, which are common in patients with leukemia.
How serious is the interaction between Fluconazole and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes (potassium, magnesium, calcium) before treatment and monitor periodically, correcting abnormalities. Consider an alternative antifungal with less QT effect if the QTc becomes prolonged.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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