Drug interactions
Fluconazole + Hydroxyprogesterone caproate
Severity: Minor
Fluconazole and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so fluconazole may increase its exposure. The clinical consequence is likely small given the depot formulation and its wide safety margin.
What this interaction means in plain words
Fluconazole and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluconazole inhibits CYP3A4, which may modestly slow hydroxyprogesterone caproate metabolism.
What to do
No dose adjustment is generally needed; be aware of possible increased progestogenic adverse effects such as fluid retention or injection-site reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Fluconazole and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so fluconazole may increase its exposure. The clinical consequence is likely small given the depot formulation and its wide safety margin.
How serious is the interaction between Fluconazole and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; be aware of possible increased progestogenic adverse effects such as fluid retention or injection-site reactions.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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