Drug interactions
Fluconazole + Indacaterol inhaled
Severity: Moderate
Fluconazole and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta2 agonist, can prolong the QT interval at high exposure and cause hypokalemia, and fluconazole may add to QT effects. Fluconazole may also modestly raise indacaterol exposure by inhibiting transporters and enzymes involved in its clearance, although clinical relevance at standard doses is limited.
What this interaction means in plain words
Fluconazole and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and possible increase in indacaterol exposure through inhibition of its clearance.
What to do
Use the usual inhaled dose and monitor for palpitations and arrhythmia in patients with cardiac disease. Check potassium and consider an ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Fluconazole and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta2 agonist, can prolong the QT interval at high exposure and cause hypokalemia, and fluconazole may add to QT effects. Fluconazole may also modestly raise indacaterol exposure by inhibiting transporters and enzymes involved in its clearance, although clinical relevance at standard doses is limited.
How serious is the interaction between Fluconazole and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual inhaled dose and monitor for palpitations and arrhythmia in patients with cardiac disease. Check potassium and consider an ECG in high-risk patients.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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