Drug interactions
Fluconazole + Isradipine
Severity: Moderate
Fluconazole and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is metabolized by CYP3A4, and fluconazole may increase its concentrations. This can cause excessive vasodilation with hypotension, peripheral edema, flushing or headache.
What this interaction means in plain words
Fluconazole and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4, reducing first-pass and systemic clearance of isradipine.
What to do
Monitor blood pressure and heart rate when starting or stopping fluconazole, and reduce the isradipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Isradipine?
MediHelp rates the interaction as moderate. Fluconazole and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine is metabolized by CYP3A4, and fluconazole may increase its concentrations. This can cause excessive vasodilation with hypotension, peripheral edema, flushing or headache.
How serious is the interaction between Fluconazole and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping fluconazole, and reduce the isradipine dose if hypotension or edema develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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