Drug interactions
Fluconazole + Lansoprazole
Severity: Minor
Fluconazole and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP3A4, the two main enzymes clearing lansoprazole, so lansoprazole exposure can increase. Because lansoprazole is well tolerated, this is usually of limited consequence unless high doses or long courses are used.
What this interaction means in plain words
Fluconazole and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Fluconazole inhibits CYP2C19 and CYP3A4, reducing lansoprazole clearance.
What to do
No routine adjustment is needed; consider reducing the lansoprazole dose if adverse effects occur with prolonged high-dose use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Lansoprazole?
MediHelp rates the interaction as minor. Fluconazole and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole inhibits CYP2C19 and CYP3A4, the two main enzymes clearing lansoprazole, so lansoprazole exposure can increase. Because lansoprazole is well tolerated, this is usually of limited consequence unless high doses or long courses are used.
How serious is the interaction between Fluconazole and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider reducing the lansoprazole dose if adverse effects occur with prolonged high-dose use.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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