Drug interactions
Fluconazole + Mestranol
Severity: Minor
Fluconazole and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is a prodrug of ethinyl estradiol. Fluconazole may modestly increase estrogen exposure through CYP3A4 inhibition, which could increase estrogenic adverse effects such as nausea, breast tenderness, or thromboembolic risk, though the effect is generally small.
What this interaction means in plain words
Fluconazole and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluconazole inhibits CYP3A4, slightly reducing estrogen metabolism.
What to do
No dose adjustment is routinely needed; advise patients to report estrogenic adverse effects. Contraceptive efficacy is not expected to be reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Mestranol?
MediHelp rates the interaction as minor. Fluconazole and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mestranol is a prodrug of ethinyl estradiol. Fluconazole may modestly increase estrogen exposure through CYP3A4 inhibition, which could increase estrogenic adverse effects such as nausea, breast tenderness, or thromboembolic risk, though the effect is generally small.
How serious is the interaction between Fluconazole and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; advise patients to report estrogenic adverse effects. Contraceptive efficacy is not expected to be reduced.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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