Drug interactions
Fluconazole + Mipomersen
Severity: Moderate
Fluconazole and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen is associated with hepatotoxicity, including transaminase elevations and hepatic steatosis, and fluconazole can also raise liver enzymes. Together they may increase the risk of liver injury.
What this interaction means in plain words
Fluconazole and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor liver enzymes and bilirubin more frequently when combined. Discontinue or reassess therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Mipomersen?
MediHelp rates the interaction as moderate. Fluconazole and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen is associated with hepatotoxicity, including transaminase elevations and hepatic steatosis, and fluconazole can also raise liver enzymes. Together they may increase the risk of liver injury.
How serious is the interaction between Fluconazole and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin more frequently when combined. Discontinue or reassess therapy if transaminases rise significantly.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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