Drug interactions
Fluconazole + Nitrendipine
Severity: Moderate
Fluconazole and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine undergoes extensive CYP3A4 metabolism, so fluconazole may raise its levels. This can lead to hypotension, flushing, headache and edema.
What this interaction means in plain words
Fluconazole and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4, decreasing nitrendipine clearance.
What to do
Monitor blood pressure and edema when fluconazole is started or stopped, and lower the nitrendipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Nitrendipine?
MediHelp rates the interaction as moderate. Fluconazole and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrendipine undergoes extensive CYP3A4 metabolism, so fluconazole may raise its levels. This can lead to hypotension, flushing, headache and edema.
How serious is the interaction between Fluconazole and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when fluconazole is started or stopped, and lower the nitrendipine dose if hypotension occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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