Drug interactions
Fluconazole + Octreotide
Severity: Moderate
Fluconazole and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and fluconazole also prolongs the QT interval, so the combination may increase arrhythmia risk. The clinical significance is greatest with bradycardia, electrolyte disturbance or heart disease.
What this interaction means in plain words
Fluconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization, with octreotide-induced bradycardia adding to risk.
What to do
Monitor ECG and correct potassium and magnesium abnormalities during combined use. Avoid in patients with congenital long QT or significant bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Fluconazole with Octreotide?
MediHelp rates the interaction as moderate. Fluconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and fluconazole also prolongs the QT interval, so the combination may increase arrhythmia risk. The clinical significance is greatest with bradycardia, electrolyte disturbance or heart disease.
How serious is the interaction between Fluconazole and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium abnormalities during combined use. Avoid in patients with congenital long QT or significant bradycardia.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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