Drug interactions
Fluconazole + Olanzapine
Severity: Moderate
Fluconazole and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small QT-prolonging effect and fluconazole has recognized QT liability. Together they may modestly increase arrhythmia risk, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Fluconazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Olanzapine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation; olanzapine is mostly cleared by CYP1A2 and glucuronidation so little pharmacokinetic effect is expected.
What to do
Check baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG if other QT-prolonging drugs or cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Fluconazole with Olanzapine?
MediHelp rates the interaction as moderate. Fluconazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small QT-prolonging effect and fluconazole has recognized QT liability. Together they may modestly increase arrhythmia risk, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Fluconazole and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG if other QT-prolonging drugs or cardiac risk factors are present.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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