Drug interactions
Fluconazole + Olaparib
Severity: Major
Fluconazole and Olaparib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise olaparib levels, increasing the risk of anemia, nausea, fatigue and other dose-related toxicities. Olaparib is metabolized mainly by CYP3A4.
What this interaction means in plain words
Fluconazole and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Olaparib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4, decreasing olaparib clearance.
What to do
Avoid if possible. If necessary, reduce olaparib to 200 mg twice daily (capsule) or 150 mg twice daily (tablet) and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Fluconazole with Olaparib?
MediHelp rates the interaction as major. Fluconazole and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can raise olaparib levels, increasing the risk of anemia, nausea, fatigue and other dose-related toxicities. Olaparib is metabolized mainly by CYP3A4.
How serious is the interaction between Fluconazole and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, reduce olaparib to 200 mg twice daily (capsule) or 150 mg twice daily (tablet) and monitor blood counts.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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