Drug interactions
Fluconazole + Olodaterol inhaled
Severity: Moderate
Fluconazole and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olodaterol is a long-acting beta2 agonist that can cause tachycardia, hypokalemia, and QT effects, and fluconazole may add to QT prolongation. The risk is mainly relevant in patients with underlying cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Fluconazole and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta2-agonist cardiovascular effects.
What to do
Monitor for palpitations and arrhythmias, and check potassium in at-risk patients. Obtain an ECG if symptoms develop or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Fluconazole and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olodaterol is a long-acting beta2 agonist that can cause tachycardia, hypokalemia, and QT effects, and fluconazole may add to QT prolongation. The risk is mainly relevant in patients with underlying cardiac disease or electrolyte disturbances.
How serious is the interaction between Fluconazole and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmias, and check potassium in at-risk patients. Obtain an ECG if symptoms develop or other QT-prolonging drugs are present.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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