Drug interactions
Fluconazole + Paclitaxel protein bound
Severity: Moderate
Fluconazole and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, and fluconazole may modestly increase exposure through CYP3A4 inhibition. Higher exposure could worsen neutropenia and neuropathy, though the effect is expected to be limited.
What this interaction means in plain words
Fluconazole and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4, a secondary elimination pathway of paclitaxel.
What to do
Monitor blood counts and neuropathy symptoms, and reduce the paclitaxel dose per protocol if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Fluconazole and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and fluconazole may modestly increase exposure through CYP3A4 inhibition. Higher exposure could worsen neutropenia and neuropathy, though the effect is expected to be limited.
How serious is the interaction between Fluconazole and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms, and reduce the paclitaxel dose per protocol if toxicity emerges.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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