Drug interactions
fluconazole + phenytoin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ phenytoin levels/toxicity.
Mechanism of action
CYP2C9/2C19 inhibition.
Clinical management
Monitor and adjust phenytoin dose.
Drug reference
References
Frequently asked questions
Can I take fluconazole with phenytoin?
The interaction is rated: Major. ↑ phenytoin levels/toxicity.
How serious is the interaction between fluconazole and phenytoin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between fluconazole and phenytoin managed?
Monitor and adjust phenytoin dose.
Why do fluconazole and phenytoin interact?
CYP2C9/2C19 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.