Drug interactions
Fluconazole + Rifampin
Severity: Moderate
Fluconazole and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin lowers fluconazole concentrations, which may reduce antifungal efficacy and risk treatment failure. The effect is of moderate size but can matter in serious fungal infections.
What this interaction means in plain words
Fluconazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces hepatic drug-metabolizing enzymes, increasing fluconazole clearance.
What to do
Monitor clinical response to antifungal therapy and consider a higher fluconazole dose if response is inadequate. Consider an alternative to rifampin where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Rifampin?
MediHelp rates the interaction as moderate. Fluconazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin lowers fluconazole concentrations, which may reduce antifungal efficacy and risk treatment failure. The effect is of moderate size but can matter in serious fungal infections.
How serious is the interaction between Fluconazole and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider a higher fluconazole dose if response is inadequate. Consider an alternative to rifampin where feasible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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