Drug interactions
Fluconazole + Saccharomyces boulardii
Severity: Moderate
Fluconazole and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is an antifungal and may reduce the viability of the yeast probiotic Saccharomyces boulardii, which could lessen its benefit. In immunocompromised patients the yeast has also caused fungemia, which fluconazole would treat.
What this interaction means in plain words
Fluconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Direct antifungal activity of fluconazole against the probiotic yeast.
What to do
If both are required, avoid relying on the probiotic during antifungal therapy, or consider a bacterial probiotic instead. Avoid S.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Fluconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is an antifungal and may reduce the viability of the yeast probiotic Saccharomyces boulardii, which could lessen its benefit. In immunocompromised patients the yeast has also caused fungemia, which fluconazole would treat.
How serious is the interaction between Fluconazole and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are required, avoid relying on the probiotic during antifungal therapy, or consider a bacterial probiotic instead. Avoid S.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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