Drug interactions
Fluconazole + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Minor
Fluconazole and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause fluid and electrolyte shifts, which may predispose to QT prolongation when combined with a QT-prolonging drug such as fluconazole. The interaction is mainly relevant in patients with cardiac disease or other risk factors.
What this interaction means in plain words
Fluconazole and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Electrolyte disturbance from bowel cleansing may add to the QT-prolonging effect of fluconazole.
What to do
Maintain hydration and check electrolytes in patients with cardiac risk factors or on several QT-prolonging drugs. No routine change is needed otherwise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as minor. Fluconazole and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bowel preparations can cause fluid and electrolyte shifts, which may predispose to QT prolongation when combined with a QT-prolonging drug such as fluconazole. The interaction is mainly relevant in patients with cardiac disease or other risk factors.
How serious is the interaction between Fluconazole and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and check electrolytes in patients with cardiac risk factors or on several QT-prolonging drugs. No routine change is needed otherwise.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
