Drug interactions
Fluconazole + Tezacaftor
Severity: Moderate
Fluconazole and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases tezacaftor exposure, which may raise the likelihood of adverse effects of the combination product.
What this interaction means in plain words
Fluconazole and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of tezacaftor.
What to do
Follow the combination product label for reduced dosing with moderate CYP3A inhibitors, typically alternating regimens. Monitor liver function and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Tezacaftor?
MediHelp rates the interaction as moderate. Fluconazole and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole increases tezacaftor exposure, which may raise the likelihood of adverse effects of the combination product.
How serious is the interaction between Fluconazole and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the combination product label for reduced dosing with moderate CYP3A inhibitors, typically alternating regimens. Monitor liver function and tolerability.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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