Drug interactions
Fluconazole + Triamcinolone acetonide injectable
Severity: Moderate
Fluconazole and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise triamcinolone exposure, increasing systemic corticosteroid effects including adrenal suppression and Cushingoid features. Cases have been described with CYP3A4 inhibitors and injected triamcinolone.
What this interaction means in plain words
Fluconazole and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4, reducing triamcinolone clearance.
What to do
Monitor for signs of corticosteroid excess such as hyperglycemia and Cushingoid features, and consider a lower triamcinolone dose or longer interval between injections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Fluconazole and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may raise triamcinolone exposure, increasing systemic corticosteroid effects including adrenal suppression and Cushingoid features. Cases have been described with CYP3A4 inhibitors and injected triamcinolone.
How serious is the interaction between Fluconazole and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as hyperglycemia and Cushingoid features, and consider a lower triamcinolone dose or longer interval between injections.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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